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Why cAMP? In the field of life sciences, there is a molecule widely regarded as the “gold standard” of signal transduction research—cyclic adenosine monophosphate (cAMP). Since its Nobel Prize–level discovery in 1957, this tiny “second messenger,” composed o

Over half of the global population meets the diagnostic criteria for at least one psychiatric disorder in their lifetime, and "comorbidity" (having multiple disorders simultaneously) is common. Does the traditional diagnostic boundary still hold? A recent study in Nature shows, for the fir

Title：SENP6 Restrains NLRP3 Inflammasome Activation via DeSUMOylation-Driven K48-Linked Ubiquitination of NLRP3 in Acute Lung Injury Levels of IL-1β, IL-18, and TNF-α in the supernatants of peritoneal macrophages from SENP6^fl/fl and SENP6^fl/fl Lyz2-Cre mice following LPS priming

In ELISA experiments, the sufficient lysis of tissue samples and protein extraction are crucial steps determining the success of the experiment. Today, we will share the detailed operating conditions and precautions for several mainstream lysis methods.   Liquid Nitrogen Grinding Method

When patients with hyperlipidemia suffer from infectious bone defects (IBD), are traditional treatments helpless? A team from Shandong First Medical University has published a groundbreaking study in the Chemical Engineering Journal: they have developed an injectable multifunctional hydrogel that in

Water is one of the primary molecules of life, which is why the majority of our bodies are composed of it. As a child, I struggled to comprehend this—shouldn’t we be relatively fluid then? I don’t think I ever found a satisfactory answer, nor did I truly seek one until I learned ab