HIF-1:The "Master Switch" of the Hypoxic Microenvironment – A Comprehensive Guide to This Core Tumor Regulator
Hypoxia is the most prevalent and lethal microenvironmental characteristic within solid tumors. The central executor of cellular responses to hypoxia is a class of key transcription factors known as HIF-1, which governs cancer cell survival, metabolism, angiogenesis, metastasis, and drug resistance,