Catalog Number：RA20342
SGT1/ECD Rabbit Polyclonal Antibody
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Size：
50 μL
100 μL
Price：
$149.00
$249.00
Delivery： Order now, ship in 3 days
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| Product Name | SGT1/ECD Rabbit Polyclonal Antibody | Species | H,M,R |
| Applications | WB | ||
| Condition | 1mg/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol. | ||
| Alternative Names | ECD,hSGT1,human suppressor of GCR two,suppressor of GCR2,SGT1 protein | ||
| Store | Store at -20°C. Stable for one year from the date of shipment. | ||
| Recommended dilutions | WB 1:2,000-5,000 | ||
| Specificity | Antibody can detect endogenous SGT1/ECD proteins. | ||
| Background | Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). [UniProt] | ||
| Molecular Weight | 73KD | Isotype | IgG |
| GeneID | 11319 | Protein MW | ~73KD |
| SWISS | O95905 | Source | Rabbit |
| Antigen | Recombinant Protein | Category | Polyclonal |
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Western blot analysis of 1)Hela Cell, 2)293T Cell, 3)Mouse Brain Tissue, 4)Rat Brain Tissue Lysate using SGT1/ECD Rabbit polyclonal Antibody diluted at 1:2,000.